Sarcoidosis, Tuberculosis
Conditions
Keywords
Angiotensin converting enzyme, Lysozyme, Ankylosing spondylitis, Behcet's disease, Sarcoidosis, Syphilis, Tuberculosis, Ocular inflammation
Brief summary
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
Detailed description
Increased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease. Sarcoidosis, ankylosing spondylitis and Behcet's disease are the most common autoimmune inflammatory diseases involving the eye. Elevated serum angiotensin converting enzyme levels have also been reported in tuberculosis. Syphilis and tuberculosis are the most common infectious diseases involving the eye.
Interventions
OTHERspectrophotometric assay
measurement of enzyme activity in the serum
OTHERradial immunodiffusion
measurement of the precipitated ring diameters showing enzyme activity in the serum
Sponsors
Ozlem Sahin
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
9 Years to 86 Years
Healthy volunteers
No
Inclusion criteria
* Subjects have ocular inflammation diagnosed as sarcoidosis, ankylosing spondylitis, behcet's disease * Subjects have ocular infection diagnosed as tuberculosis and syphilis * Subjects have refractive errors only
Exclusion criteria
* Subjects using ACE inhibitors, systemic steroids, immunosuppressive or immunomodulatory therapies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analysis of serum angiotensin converting enzyme level | 1 day |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of serum lysozyme level | 1 day |
Countries
Turkey (Türkiye)
Contacts
Primary Contactozlem sahin, MD
Backup ContactEda Karaismailoglu, MS
Outcome results
None listed