Physical Activity
Conditions
Keywords
knee osteoarthritis, hyaluronic acid, corticosteroid, intra-articular injection, therapeutic effect
Brief summary
Using double blind, randomized controlled design to study the immediate, short-term and intermediate-term therapeutic effects of ultrasound guided hyaluronic acid injection and hyaluronic acid combined corticosteroid injection to patients with knee osteoarthritis.
Detailed description
A total of 76 patients will be collected. The participants will be randomized into two groups, including hyaluronic acid injection group and hyaluronic acid combined corticosteroid injection group. Physical activity will be evaluated. The hyaluronic acid group will receive three times of hyaluronic acid injection per week in three weeks; the hyaluronic acid combined corticosteroid group will receive hyaluronic acid combined corticosteroid injection in the first week, followed by hyaluronic acid injection at the second and third week. Re-evaluation will be arranged at after one week of injection, after two weeks of injection, one week after injection, one month after injection, three months after injection, and six month after injection.
Interventions
OTHERhyaluronic acid
compare the therapeutic effects of hyaluronic acid injection and hyaluronic acid combined corticosteroid injection to patients with knee osteoarthritis
OTHERhyaluronic acid combined corticosteroid
compare the therapeutic effects of hyaluronic acid injection and hyaluronic acid combined corticosteroid injection to patients with knee osteoarthritis
Sponsors
Shin Kong Wu Ho-Su Memorial Hospital
Taipei Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Osteoarthritis of knee with Kellgren/Lawrence grade II or III
Exclusion criteria
* Who have implant in knee * History of neurological deficit, such as stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| physical activity | changes from baseline at after one week of injection, after two weeks of injection, one week after injection, one month after injection, three months after injection, and six month after injection |
Secondary
| Measure | Time frame |
|---|---|
| functional performance (Western Ontario and McMaster Universities Osteoarthritis index) | changes from baseline at after one week of injection, after two weeks of injection, one week after injection, one month after injection, three months after injection, and six month after injection |
| functional performance (Knee injury and Osteoarthritis Outcome Score) | changes from baseline at after one week of injection, after two weeks of injection, one week after injection, one month after injection, three months after injection, and six month after injection |
Countries
Taiwan
Outcome results
None listed