Water Intake and Glycemic Response : Preliminary Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02625363

Enrollment

Registered

2015-12-09

Start date

2015-11-30

Completion date

2015-12-31

Last updated

2015-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Glycemic Index, Water Intake, Glycemic Response

Brief summary

Glycemic index concept is widely used to determine impact of a food to blood glucose. Several studies showed that water content and intake after meal may influence glycemic response of the meal and thus have an effect on the result of GI measurement. Currently these studies found conflicting results. Therefore, this study aims to determine whether water intake, specifically after meal, may influence the glycemic response and glycemic index value of the meal.

Detailed description

Glycemic index methods are performed according to Food and Agricultural Organization/WHO recommendations.

Interventions

OTHERGlucose Ref - Std

First, fasting blood glucose was measured. Then, subjects consumed the glucose sample in 5-10 minutes and blood sugar level were measured at 0', 15', 30', 45', 60', 90', and 120'

OTHERGlucose Ref and 450 ml water

First, fasting blood glucose was measured. Then, subjects consumed the glucose sample in 5-10 minutes. Subjects given additional 150 ml water at 45, 75, and 105 minutes and blood sugar level were measured at 0', 15', 30', 45', 60', 90', and 120

OTHERWhite Bread with 250 ml water

First, fasting blood glucose was measured. Then, subjects consumed the samples in 10-15 minutes and blood sugar level were measured at 0', 15', 30', 45', 60', 90', and 120'

OTHERWhite Bread and 700 ml water

Sample consumed with 250 ml water immediately after meal consumption, and additional 150 ml water at 45, 75, and 105 minutes. First, fasting blood glucose was measured. Then, subjects consumed the samples in 10-15 minutes and blood sugar level were measured at 0', 15', 30', 45', 60', 90', and 120'

OTHERWhite Bread with 125 ml water (twice)

Sample consumed with 125 ml water immediately after meal consumption, and additional 125 ml water after 60 minutes First, fasting blood glucose was measured. Then, subjects consumed the samples in 10-15 minutes and blood sugar level were measured at 0', 15', 30', 45', 60', 90', and 120'

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Age between 20-40 years * fasting blood glucose 70-99 mg/dL * Indonesians

Exclusion criteria

* having diabetes * smoking * if women, pregnant or lactating * being allergic to food used in this study * having gastrointestinal disturbance * in regular medication * refusal to sign the consent form

Design outcomes

Primary

Measure	Time frame	Description
2 h postprandial blood glucose level (Glycemic Response)	fasting 0 min, 15 min, 30 min, 45 min, 60 min, 90 min, 120 min	—
Glycemic index value of meal (white bread)	fasting 0 min, 15 min, 30 min, 45 min, 60 min, 90 min, 120 min	The glycemic index is a calculated from measurements of area under the glucose curve after the food is eaten, divided by the corresponding area after the control food is eaten. The value is multiplied by 100 to represent a percentage of the reference food.

Countries

Indonesia

Contacts

Primary ContactVanessa Yolanda, SSi

vanessa.yolanda@nutrifood.co.id

Backup ContactLina Antono, MSc

lina.antono@nutrifood.co.id

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026