Healthy
Conditions
Brief summary
Dairy products consumption is widely recommended in a healthy diet not only for bone growth and maintenance, but also as a protein, calcium and magnesium sources for an adequate diet. However, dairy products are a major dietary source of saturated fat that is associated with increased risk of coronary heart disease. ln this context, dietary guidelines still advocate a restriction in dietary saturated fat for optimal heart health. Nevertheless, the association between saturated fat and the risk of heart disease remains highly controversial within the scientific community. There is also emerging evidence that the impact of dietary saturated fat will be significantly influenced by the food matrix through which it is provided. Recent studies indicate that cheese could have a major influence on intestinal fat absorption and the magnitude of the after meal release of fat in blood circulation. This is of interest because substantial evidence exists indicating that elevated levels of the after meal fat levels are associated with increased cardiovascular risk. Therefore, the improvement of the after meal fat levels produced by cheese consumption could well be part of novel therapeutic approaches contributing to improve cardiovascular risk. The general objective of the proposed research is to investigate how cheese consumption affects the after meal release of fat in blood circulation in healthy subjects. Our hypothesis is that, compared to butter, cheese consumption will have a beneficial impact on the after meal fat levels in healthy subjects. Favourable results from the proposed study will provide novel and much warranted evidence on the importance of considering changes in the after meal fat levels, not only bad cholesterol, as part of the on-going saturated fat-heart disease debate and that cheese should indeed be part of a healthy diet.
Interventions
OTHERTest meal (butter)
Subjects will eat one meal test containing 33g of lipids from butter (percent of total caloric intake: 15.0% from proteins; 53.0% from carbohydrates; 32.0% from fat).
OTHERTest meal (cheddar cheese)
Subjects will eat one meal test containing 33g of lipids from cheddar cheese (percent of total caloric intake: 15.0% from proteins; 53.0% from carbohydrates; 32.0% from fat).
OTHERTest meal (cream cheese)
Subjects will eat one meal test containing 33g of lipids from cream cheese (percent of total caloric intake: 15.0% from proteins; 53.0% from carbohydrates; 32.0% from fat).
Sponsors
Laval University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 18-65 years (men and women)
Exclusion criteria
* Smokers (more than 1 cigarette/d) * Body weight variation more than 10% during the last 6 months prior to the study baseline * BMI more than 35 kg/m2 * Previous history of cardiovascular disease * Subjects with type 2 diabetes * Subjects with monogenic dyslipidemia * Subjects taking anti-inflammatory drugs * Subjects with endocrine or gastrointestinal disease * Allergy/intolerance to dairy * Clinical use of vitamin D and calcium supplements * Vegetarians * Subjects who are in situation or have a condition that, in the opinion of the investigators, may interfere with optimal participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in triglyceride concentrations 4h following the test meals ingestion | At week 0, week 2 and week 4 (at the end of the three test meals). |
Secondary
| Measure | Time frame |
|---|---|
| Change in triglyceride concentrations (area under the curve) following the test meals ingestion | At week 0, week 2 and week 4 (at the end of the three test meals). |
| Change in free fatty acids concentrations (area under the curve) following the test meals ingestion | At week 0, week 2 and week 4 (at the end of the three test meals). |
| Change in apolipoprotein B48 concentrations (area under the curve) following the test meals ingestion | At week 0, week 2 and week 4 (at the end of the three test meals). |
Countries
Canada
Outcome results
None listed