Plasma Exchange vs Conservative Management in Non-severe Acute Hypertriglyceridemic Pancreatitis

Comparison of Plasma Exchange and Conservative Management in Non-severe Acute Hypertriglyceridemic Pancreatitis With Mildly Elevated Triglycerides

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02622854

Enrollment

Registered

2015-12-07

Start date

2016-06-30

Completion date

2020-08-31

Last updated

2023-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Pancreatitis

Keywords

plasma exchange, hypertriglyceridemia

Brief summary

To compare effectiveness in reducing triglycerides between daily plasma exchange and glucose+insulin infusion in patients with non-severe acute hypertriglyceridemic pancreatitis with mildly elevated triglycerides

Interventions

PROCEDUREplasma exchange

see arm description

DRUGconservative treatment

see arm description

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* mild acute hypertriglyceridemic pancreatitis * triglycerides \>15 but \< 40 mmol/l

Exclusion criteria

* pregnancy * severe course of pancreatitis

Design outcomes

Primary

Measure	Time frame	Description
decrease in triglycerides	within first 24 h after admission	as % of starting value

Secondary

Measure	Time frame	Description
time until triglycerides drop to <10 mmol/l	by the end of hospital stay, up to 100 days	expressed in days
highest C-reactive protein (CRP)	by the end of hospital stay, up to 100 days	—
% of patients with severe pancreatitis	by the end of hospital stay, up to 100 days	—

Countries

Slovenia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026