Metabolic Rate, Plasma Glucose, Sense of Satiety, Serum Insulin, Serum Triglycerides
Conditions
Brief summary
About thirty participants, of varying degrees of obesity or being non-obese, without serious concomitant diseases consume either a high- or a low- carbohydrate beverage. The beverage is also consumed either as one single drink or as 5 small portions in the morning and are tested for effects on major cardiovascular risk markers and on metabolic rate for three hours on each occasion.
Detailed description
Thirty participants come to the metabolic ward at about 8 o´clock in the fasting state and stay until lunch on four occasions each. The participants are randomized to the order of the test meals. The meals have a total caloric content of 750 kcal and have either 50% of energy from carbohydrates (low fat) or 20% of energy from carbohydrates (low carb.). The meals are consumed on one occasion in the morning or divided in 5 portions (150 kcal each) for every 30 minutes, i.e. total combinations of meal composition and of meal distribution is 4. Effects of the food on p-glucose, s-insulin, blood-lipids, hormones and on metabolic rate is measured by blood tests or by indirect calorimetry (for metabolic rate). Sense of satiety is measured by visual analogue scales.
Interventions
OTHERtwo test meals with two different macronutrient compositions
Either a high or a low carb meal either as one large or as 5 small meals. ie a crossover trial with one arm
Sponsors
University Hospital, Linkoeping
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy participants \> 18 years with or without obesity
Exclusion criteria
* Major illnesses, * thyroid diseases, * need to take prednisolone, * psychiatric disease, * inability to understand Swedish
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic rate | During about 3 hours | The metabolic rate is measured before (baseline) and there after repeatedly during 3 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effects on glucose and insulin | 3 hours | Repeated test of glucose and insulin for three hours after test meal |
Countries
Sweden
Outcome results
None listed