Cerebral Microembolism in the Critically Ill With Acute Kidney Injury

Cerebral Microembolism in the Critically Ill With Acute Kidney Injury: A Prospective Multi-Center Randomized Controlled Trial Comparing Continuous With Intermittent Renal Replacement Therapy.

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02621749

Acronym

COMET-AKI

Enrollment

Registered

2015-12-03

Start date

2017-01-31

Completion date

2022-11-06

Last updated

2022-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Embolism

Brief summary

The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.

Interventions

DEVICERenal replacement therapy

Patients receive renal replacement therapy according to institutional standards

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* \> 18 yrs. * Signed IC

Exclusion criteria

* Heart disease (PFO, ASD, VSD, severe valvular disease) * Atrial fibrillation * Cerebrovascular pathology * Missing temporal bone window * Allergy to plastic contained in the investigative device (transcranial Doppler) * Chronic kidney disease * Pregnancy * Participation in another study

Design outcomes

Primary

Measure	Time frame
Cerebral Microembolic Load detected by Transcranial Doppler Ultrasound	During hemodialysis therapy

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026