Healthy
Conditions
Keywords
Memory, Resveratrol, elderly, cognition
Brief summary
The study will investigate whether resveratrol could provide positive effects on memory and brain structures and functions in healthy elderly participants.
Detailed description
Cell and animal studies postulated various beneficial effects of resveratrol, ranging from a reduction of inflammatory processes and the treatment of cancer to the prevention of cardiovascular diseases and stroke. With regard to cognitive decline, rodent models for Alzheimer's disease (AD) showed improved learning and decelerated hippocampal neurodegeneration after intake of resveratrol. Animal and first human studies provided evidence that resveratrol might serve as an easy, cost-effective option to develop novel prevention and treatment strategies against age-associated cognitive decline. To test this hypothesis, the researchers study general brain structure and function on healthy older individuals (\> 60years old).
Interventions
DIETARY_SUPPLEMENTresveratrol supplementation
6 months of resveratrol supplementation
DIETARY_SUPPLEMENTPlacebo
6 months of placebo intake
Sponsors
University of Leipzig
Evolva SA
Max Planck Institute for Human Cognitive and Brain Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* subjects who are healthy or with subjective memory complaints * older than 60 years old * normal to overweight participants (BMI: 22-40 kg/sqm)
Exclusion criteria
* dementia * Psychiatric diseases * severe untreated internal diseases * diabetes * younger than 60 years * BMI \< 22 or \>40
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline Verbal Learning Task Scores at 6 months | Baseline (timepoint 0), after 6 months (timepoint 6 months) |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline Verbal Learning Task Scores at 12 months | after 12 months (timepoint 12 months) |
| Mini Mental State Examination | Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months) |
| Structural changes on the brain MRI images | Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months) |
| Functional changes on the brain MRI images | Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months) |
| Plasma biomarkers | Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months) |
Countries
Germany
Outcome results
None listed