Helium Oxygen Mixture in the Treatment of Meconium Aspiration Syndrome

Study on the Effect of Helium Oxygen Mixture in the Treatment of Meconium Aspiration Syndrome Parallel Synchronized Intermittent Mandatory Ventilation; Synchronous Maudatory Ventilation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02620891

Enrollment

Registered

2015-12-03

Start date

2015-02-01

Completion date

2017-04-01

Last updated

2020-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal Meconium Aspiration

Keywords

helium oxygen mixture, Meconium aspiration syndrome

Brief summary

Helium-oxygen mixture(heliox) was suggested to be beneficial in meconium aspiration syndrome in previous studies，but the evidence was limited．The aim of the study was to assess the effectiveness of synchronize intermittent mandatory ventilation (SIMV) with heliox (70% helium and 30% oxygen) on length of ventilation(LoV) and cardiopulmonary protection in meconium aspiration syndrome.

Interventions

DEVICEhelium oxygen mixture

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

37 Weeks to 40 Weeks

Healthy volunteers

Yes

Inclusion criteria

* Subject has the diagnosis of neonatal meconium aspiration syndrome * Subject has Synchronous instruction ventilation

Exclusion criteria

* History of congenital or hereditary disease

Design outcomes

Primary

Measure	Time frame	Description
blood gas analysis	2 hour	Time detection after treatment

Secondary

Measure	Time frame
Inflammatory response index (IL-6,IL-8, TNF-a,CRP)	0 hour

Other

Measure	Time frame
Amplitude integrated electroencephalogram	28and 100 days

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026