Acne Vulgaris
Conditions
Keywords
acne, sebaceous gland, lipid, sebum
Brief summary
There are two purposes of this study: 1. First, the investigators want to see what the differences are in de novo sebaceous lipid production of people with and without acne. 2. Secondly, the investigators want to know what happens to sebaceous gland de novo lipid production before and after treatment with topical tretinoin and oral isotretinoin.
Detailed description
The primary objective of this study is to understand how de novo lipid production of sebaceous glands are altered in acne and with acne directed therapy. Hypothesis 1: The overall de novo lipogenesis will be increased in those with acne Hypothesis 2: Treatment with topical tretinoin and systemic isotretinoin will reduce de novo lipogenesis.
Interventions
DRUGTretinoin
Subjects will apply 0.5% tretinoin cream nightly to their face for a total of 12 weeks.
DRUGIsotretinoin
Subjects will take isotretinoin as prescribed by their dermatologist.
Sponsors
University of California, Davis
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 15 to 45 years of age * Subject/Parents/Legal Guardian be able to read and comprehend study procedure and consent forms * Have acne that is diagnosed by a board certified dermatologist * Meet one of the following criteria: * already been prescribed oral isotretinoin for treatment of acne * have already been prescribed a topical retinoid * eligible for prescription of topical tretinoin
Exclusion criteria
* Those who have already initiated or completed a course of systemic isotretinoin * Those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome * Those who are pregnant in female participants * Those who do not fit the inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sebumeter measurement differences before and after treatment with isotretinoin | 3 months |
| Change in the fractional contribution of DNL to the total sebum palmitate before and after treatment with isotretinoin at baseline and 3 months after treatment. | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Change in the lesion counts of inflammatory and non-inflammatory lesions. | 3 months |
| Change in the global acne grade score | 3 months |
| Difference in the fractional contribution of DNL to the sebum total palmitate before and after treatment with a topical retinoid (adapalene, tazarotene, or tretinoin). | 3 months |
| Difference in the fractional contribution of de novo lipogenesis (DNL) to the sebum total palmitate between those with and without acne | 3 months |
| Change in the investigator global assessment of acne | 3 months |
Countries
United States
Outcome results
None listed