Infertility
Conditions
Brief summary
Back ground: A single dose of GnRH analogue in the luteal phase is reported to improve the outcome of IVF/ICSI treatments but the effect in FET cycles has not been reported. Aim: To compare the results of frozen thawed embryo transfers with and without GnRHa analogue support Primary end point: IR, PR, on going PR Secondary end point: hCH, E2 and progesterone levels 14 days after thawing
Interventions
DRUGNatural cycle: Triptorelin acetate 0.1 mg
A single dose of triptorelin acetate 0.1 s.c. was giwen when the age of the transferred embryo was six days in additon to standard micronized progesterone 400 mg vaginally
DRUGHormone replacement cycle and triptorelin acetate 0.1 mg
A single dose of triptorelin acetate 0.1 s.c. was giwen when the age of the transferred embryo was six days in addition to standard Estradiol and progesterone support
Sponsors
Turku University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* 20 - 45 year old women comig to frozen thawed embryo transfer
Exclusion criteria
* The age of the woman over 42 years during the initial ICF/ICSI- treatment from which the embryos derive * Abnormal uterus * Known abnormality of karyotype of the woman or her partner * Severe male factor as an exclusive reason for subfertility * Allegy for triptorelin acetate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy rate | five weeks after the embryo transfer |
| Implantation rate | five weeks after the embryo transfer |
| Ongoing pregnancy rate | ten weeks after the embryo transfer |
Secondary
| Measure | Time frame |
|---|---|
| hCG- level | 14 days after thawing of the embryos |
Outcome results
None listed