Healthy
Conditions
Brief summary
Following brain injury (e.g. stroke), application of non-invasive brain stimulation may improve rehabilitative efforts. However, the most effective method of non-invasive brain stimulation is unknown. Paired associative stimulation (PAS) is a method of non-invasive brain stimulation that pairs an electrical peripheral nerve stimulus with a magnetic stimulus to the head. This method can be applied in a manner that increases (facilitates) or decreases (depresses) excitability within the brain. Furthermore, applying two consecutive PAS sessions within minutes of each other (called primed PAS) may augment changes in excitability more than a single PAS session alone. Thus, the purpose of this study is to compare the effect of a double PAS session (primed PAS) to the effect of a single PAS session (unprimed PAS) and a sham PAS session in healthy individuals.
Interventions
Sponsors
University of Minnesota
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DEVICE_FEASIBILITY
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* ≥ 18 and ≤ 30 years of age * Elicitable motor evoked potential from the motor cortex contralateral to the dominant hand * Elicitable N20 sensory evoked potential
Exclusion criteria
* History of neurological disease * Seizure within the past 2 years * Currently taking epileptogenic medication * Peripheral neuropathy * Cognitive impairment and/or major psychiatric disorder * Metal in the head (dental permitted) * Pacemaker or other indwelling devices * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline peak-to-peak amplitude of motor evoked potential | Immediately before and within 60 minutes following intervention | Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG). The peak-to-peak amplitude of the EMG response will be measured. |
| Change from baseline resting motor threshold | Immediately before and within 60 minutes following intervention | Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG). The lowest stimulator output needed to elicit a consistent response will be recorded. |
Outcome results
None listed