Obesity
Conditions
Brief summary
This study describes the effect of acute high intensity exercise at 70% VO2peak on inflammation, stress, appetite hormones and appetite in lean and obese children and adolescents.
Detailed description
In summary, exercise does induce a variety of metabolic mechanisms on a central and peripheral level, related to appetite other than solely gut peptides. The literature points towards a rather loose coupling when it comes to high intensity exercise and the suppression of food intake, without a clear explanation of the cause of exercise induced anorexia. This study is aimed to investigate high-intensity exercise and its effects on appetite and satiety hormones, inflammation, stress and eating behaviors on appetite and food intake. The objective of the current study is to investigate the factors contributing to exercise-induced anorexia in lean and obese children, and maximize its translation into post-exercise suppression of food intake and promotion of negative energy balance particularly in obese children. It is hypothesized that high-intensity exercise would promote a greater suppression of food intake through suppression of appetite ratings via physiological mechanisms depending on stress and inflammation rather than gut peptides.
Interventions
OTHERExercise
Exercise at 70%VO2max on a recumbent bicycle for 30 minutes to investigate the effects of exercise at high intensities on appetite and biomarkers of appetite and inflammation.
Sponsors
University of Toronto
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
10 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* 11 normal weight and 11 obese boys will be recruited for the study. Lean and obese boys aged 10-18 years, born full-term and with a normal body weight at birth, will be included in the study
Exclusion criteria
* Dieters and individuals with lactose intolerance, allergies to milk and dairy products and gastrointestinal problems will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Appetite as assessed via visual analog scales | Timeperiod of 2 hours during each study intervention. | Appetite will be assessed via visual analog scales. Each item will be scored from 0-100; 0 not hungry; 100 very hungry |
| Biomarkers of appetite | 4 timpoints during 2 hours during each study intervention. | Biomarkers of appetite will be assessed such as A. Ghrelin; GLP-1; PYY and Leptin |
| Biomarkers of Inflammation | 4 timpoints during 2 hours during each study intervention. | Biomarkers of inflammation will be assessed such as IL-6; IL-1beta; TNF-alpha; CRP |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Biomarkers of Stress | 4 timpoints during 2 hours during each study intervention. | Biomarkers of stress will be assessed such as Cortisol and Adrenalin |
Countries
Canada
Outcome results
None listed