Hyperemesis Gravidarum, Pregnancy
Conditions
Keywords
Nutrition, Hyperemesis gravidarum, Prealbumin, Questionnaire
Brief summary
This study evaluate the rate of nausea and nutritional status in patients with hyperemesis gravidarum (severe nausea and vomiting in pregnancy) and healthy pregnant women using a questionnaire (PUQE-score), self-reported food/drink intake form and blood test. The Investigators aim for developing normal range of prealbumin measurements (reference values) during first trimester of pregnancy.
Detailed description
Women affected with hyperemesis gravidarum are at severe nutritional risk. Reference values for biochemical parameters evaluating nutritional status during early pregnancy needs to be determined. The investigators will compare clinical nutritional parameters (weight gain/weight loss) with rate of nausea (PUQE-questionnaire), self-reported nutritional intake form and biochemical measurements (prealbumin) in women admitted to hospital with hyperemesis gravidarum and healthy pregnant women. For hyperemesis patients measurements will be repeated at discharge.
Interventions
OTHERPUQE-form inclusion
PUQE-form encompassing last 24 hours completion
OTHERNutritional form inclusion
Food-list form encompassing last 24 hours completion
OTHERBlood sampling inclusion
Measurement of biochemical nutrition marker(s); Prealbumin
OTHERIntervention at discharge
PUQE-form, nutritional form and Blood sampling
Sponsors
University of Bergen
Haukeland University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnant women \< 16 weeks of gestation * Admitted to hospital for hyperemesis gravidarum (HG group) with nausea and vomiting in pregnancy with at least two of following criteria; weight loss, dehydration, fluid-/electrolyte disturbances, ketonuria
Exclusion criteria
* Non-viable pregnancy diagnosed at time of inclusion * Unable to understand Norwegian * PUQE-score \>= 13 (control group) * Nausea an vomiting in pregnancy caused by other conditions than Hyperemesis gravidarum
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prealbumin in normal pregnancy | Within 24h at inclusion | Serum Prealbumin measured during first trimester of pregnancy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prealbumin related to nutritional parameters | Within 24h at inclusion | Prealbumin level correlated to PUQE-score and weight change in normal and hyperemesis pregnancies |
| Change in Prealbumin | Patients will be followed until discharge from hospital, a mean of 5 days, and blood sampling repeated at discharge | Change in Serum Prealbumin during hospital treatment of hyperemesis gravidarum |
| Prealbumin in Hyperemesis gravidarum | Within 2h from admission to hospital | Serum Prealbumin measured when admission to hospital |
Countries
Norway
Contacts
Primary ContactJone Trovik, MD, PhD
Outcome results
None listed