Cholangitis, Pancreatitis
Conditions
Brief summary
The investigators aim to evaluate the effect of Ketamine/Propofol Admixture on hemodynamic stability, recovery time ,patient & doctor satisfaction scores during Endoscopic Retrograde Cholangiopancreatography.
Interventions
propofol-ketamine 3:1 mixture(%1 15 ml propofol + 1 ml 50mg/ml ketamine+4 ml saline in a 20-ml syringe which resulted in0.25 mg.ml-1 ketamine and 0.75 mg.ml-1 propofol
DRUGPropofol
2 mg/kg I.V
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists ( I ,II )
Exclusion criteria
1. Presence of liver and/or kidney failure, neuropsychiatric disorders, morbid obesity. 2. History of substance abuse or dependence. 3. History of serious adverse effects related to anesthetics (e.g. allergic reactions), a family history of reactions to the study drugs. 4. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean arterial blood pressure from baseline of patient undergoing Endoscopic Retrograde Cholangio pancreatography | every 5 minutes up to 30minutes |
| saturation of oxygen from baseline of undergoing Endoscopic Retrograde Cholangio pancreatography | every 5 minutes up to 30 minutes |
| Heart rate( beat/minute) from baseline of patient | every 5 minutes up to 30 minutes |
| Recovery score of patient | up to 10 minutes after the end of procedure |
Secondary
| Measure | Time frame |
|---|---|
| patient and doctor satisfaction score | through study completion, an average of 1 year |
Countries
Egypt
Outcome results
None listed