Fever of Unknown Origin, Tick-borne Diseases
Conditions
Keywords
TBDs；diagnosis
Brief summary
The study will use several laboratory diagnoses in the diagnosis of patients with fever，to find out which will be more helpful for making an accurate diagnosis in the early period of Tickborne Diseases.
Detailed description
Tickborne Diseases(TBDs) spread throughout many countries and regions. In recent years, the incidence has a tendency to rise continuously. The clinical symptoms and laboratory features of tick-borne diseases are always of no specific, and the diagnostic methods available, such as observing the pathogen after cultivation or by the method of Gimenez、serological tests for antibody always can't make a timely diagnosis, especially in the early period of the disease. The development of polymerase chain reaction(PCR) has been applied for pathogen detection, and showed high sensitivity and specificity,and may contribute to early diagnose，but no standardized method of PCR has been as yet proposed. This study mean to explore several laboratory diagnoses to find out which will be more helpful for making an accurate diagnosis in the early period of TBDs.
Interventions
OTHERdiagnostic methods
explore several laboratory diagnostic methods to find out which will be more helpful for making an accurate diagnosis in the early period of TBDs.
Sponsors
Beijing Chao Yang Hospital
Beijing Friendship Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients have fever more than one week * temperature is higher than 38℃ Celsius degree * full of physical examination and laboratory examination have been carried out after one week，but still cannot make a definite diagnosis
Exclusion criteria
* fever for non-infectious diseases such as rheumatic autoimmune disease or with tumor * we find that the patient selected does not meet the selection criteria within the observation period * patients leave with automatic discharge
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evidence of immunoglobulin M and immunoglobulin G titres in acute and convalescent serum or a fragment of the specific gene from patients' whole blood | within the first 14 days in hospital |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the sensitivity and specificity of the laboratory diagnostic methods Related to the reserach | up to three years | compare the sensitivity and specificity of all the laboratory diagnostic methods, using statistical methods, to find out the most helpful one for making an accurate diagnosis in the early period of TBDs. |
Countries
China
Contacts
Primary Contactwenjie Qi, archiater
Outcome results
None listed