Placental Transfusion
Conditions
Keywords
birth, oxytocin, placental transfusion, umbilical cord clamping
Brief summary
The purpose of this study is to determine if oxytocin administration immediately after delivery of the infant modifies the volume of placental transfusion in healthy term infants.
Detailed description
Randomized controlled trial with 2 arms to test the influence of oxytocin in placental transfusion. Placental transfusion: the amount of blood that passes to the baby from the time of birth until the cord is clamped. The difference in weight between a measurement at birth and a second one after clamping the cord at 3 minutes will be considered as proxy for placental transfusion. In one arm the oxytocin will be used immediately after birth and the cord clamped at 3 minutes In the other arm the oxytocin will be administered at 3 minutes of birth after the cord is clamped.
Interventions
DRUGTiming of administration of post partum Oxytocin
10 IU of oxytocin given IV at different times after birth
Sponsors
Fundacion para la Salud Materno Infantil
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Healthy single Term pregnancies. * Vaginal delivery. * Informed consent obtained. * Presence of an investigator
Exclusion criteria
* Placenta previa. * Previous history of Postpartum hemorrhage * Intrauterine growth restriction . * Major congenital malformations. * Eclampsia * Extraction of blood sample for bank of umbilical cord stem cells. Elimination criteria: * Need for immediate assistance of the newborn * Birth weight less than 2500 g * Nuchal cord wrapped too tight * Surgically finished delivery * Short umbilical cord which might prevent placing the infant on the scale * Technical difficulties to obtain the weight
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| placental transfusion | between birth and 3 minutes of life | Difference in body weight between birth and 3 minutes of life |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| bilirubin | at 36/48 hours | Bilirubin level |
| Hematocrit | at 36/48 hours | Hematocrit levels |
| Maternal blood loss | after birth for 30 minutes | measure of the blood loss |
Countries
Argentina
Outcome results
None listed