Meibomian Gland Dysfunction
Conditions
Keywords
Meibomian gland dysfunction, Lipiview, Tear Lipid Layer
Brief summary
In this study, investigator aim to evaluate the changes of tear-film lipid layer thickness and ocular aberration after treatment of meibomian gland dysfunction. In case of stage 3 or 4 meibomian gland dysfunction, participants will be treated using conventional treatment modalities. Before treatment and after 1 and 2 months of treatment, a variety of ophthalmic examination, tear-film lipid layer thickness, and ocular aberration are going to measured and compared.
Interventions
DRUGTreatment of Meibomian gland dysfunction
artificial tears, 3% Diquafosol Tetrasodium eye drops, steroid eye drops, squeezing of meibomian glands, cleansing of eyelids.
Sponsors
Yonsei University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1\. age over 19 years old, with moderate to severe Meibomian gland dysfunction.
Exclusion criteria
1. patients with history of previous ocular or intraocular surgery 2. ocular infection, non dry eye ocular inflammation, ocular allergy, autoimmune disease 3. history of intolerance or hypersensitivity to any component of the study medications 4. wearing contact lenses during the study period, presence of current punctal occlusion 5. pregnancy, lactating women, and children
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of tear-film lipid layer thickness after treatment of meibomian gland dysfunction | 1 and 2 months after treatment of meibomian gland dysfunction | — |
| Changes of ocular aberration after treatment of meibomian gland dysfunction | 1 and 2 months after treatment of meibomian gland dysfunction | ocular parameters measured by Ray-tracing wavefront aberrometers (i-Trace, Tracey technologies , Texas ,USA) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Meibomian gland abnormality | 1 and 2 months after treatment of meibomian gland dysfunction | measured by physiological parameter (score 0,1,2,3,4) |
| Corneal erosion grade(oxford score) | 1 and 2 months after treatment of meibomian gland dysfunction | — |
| BUT(tear break-up time) | 1 and 2 months after treatment of meibomian gland dysfunction | — |
| Meibomian quality | 1 and 2 months after treatment of meibomian gland dysfunction | measured by physiological parameter (score 0,1,2,3,4) |
| OSDI(ocular surface disease index) | 1 and 2 months after treatment of meibomian gland dysfunction | — |
Countries
South Korea
Outcome results
None listed