Healthy
Conditions
Keywords
intestinal gas, Healthy subjects, microbiota, prebiotics
Brief summary
Non-absorbable, fermentable residues in the diet increase intestinal gas production and induce gas-related symptoms, such as flatulence, abdominal bloating and distention; however, prebiotics, which are also fermented by colonic bacteria have been shown to improve this type of symptoms. The aim is to demonstrate changes in metabolic activity of gut microbiota and colonic biomass induced by prebiotics. Healthy subjects (n=20) will be administered a prebiotic (Galacto-oligo-saccharide; 2.8 g/d) for 3 weeks; they will also receive a standard diet during three days. The following outcomes will be measured immediately before, at the beginning and at the end of the treatment: a) number of gas evacuations during daytime for 2 days on the standard diet, by means of an event marker; b) volume of gas evacuated via a rectal tube during 4 hours after a test meal, by means of a barostat; c) microbiota composition by fecal analysis.
Interventions
DIETARY_SUPPLEMENTBimuno Galacto-oligo-saccharide
Sponsors
Hospital Universitari Vall d'Hebron Research Institute
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
\-
Exclusion criteria
* gastrointestinal symptoms * recent (3 months) antibiotic intake * recent (3 months) change of diet * recent (3 months) gastroenteritis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of daily anal gas evacuations | Change from beginning of treatment (mean of days 2 and 3) to end of treatment (mean of days 20 and 21) |
Secondary
| Measure | Time frame |
|---|---|
| Volume of anal gas evacuation | Change from beginning of treatment (day 3) to end of treatment (day 21) |
Outcome results
None listed