Respiratory Syncytial Virus Bronchiolitis
Conditions
Keywords
Continuous Positive Airway Pressure, High Flow Oxygenation therapy, Bronchiolitis, Children
Brief summary
Bronchiolitis in infants and young children often requires respiraty support. In Denmark Continous Positive Airway Pressure ( CPAP) are routinely used in children with moderate-severe bronchiolitis. The aim of the study is to compare CPAP and High Flow Oxygenation Therapy (HFOT) as tools of respiratory support in infants and young children with bronchiolitis. Infants and young children with moderate-severe bronchiolitis and are randomized to either CPAP or HFOT.
Interventions
DEVICEOptiflow Junior
Humified air are dispensed through the system. Airflow, FiO2 (Fraction of inspired oxygen) , SpO2 (peripheral capillary Oxygen saturation) and respiratory rate are noted each hour. Progression of condition might lead to change of system og mechanical ventilation. poor tolerance might lead to change of system
Humified air are dispensed throug the system. Airflow, FiO2, SpO2 and respiratory rate are noted each hour. Progression of condition might lead to change of system or mechanical ventilation. Poor tolerance might lead to change of system.
Sponsors
Esbjerg Hospital - University Hospital of Southern Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Days to 24 Months
Healthy volunteers
No
Inclusion criteria
* infants and children with moderate respiratoric syncytial virus bronchiolitis or other viral bronchiolitis and need of respiratory support. ( clinical decision)
Exclusion criteria
* severe bronchiolitis with P C02 \> 9, decreased consciusness and risk for early progression to intensive therapy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| respiration rate | after 6 12 18 24 and 48 hour of intervention | change in respiration rate ( RR) from preintervention value |
| PCo2 | after 6 12 24 and 48 hours of intervention | Change in PCo2 (partial pressure of carbon dioxide)from pre intervention value |
| Modified asthma score (MWAS) | Once daily as long as intervention precedes ( 1-14 days) | Change in MWAS from pre intervention value |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| treatment length | from beginning of intervention to discontinuation (1-14 days) | duration of need of intervention ( hours) |
| patient acceptance of intervention | daily VAS score (0-5) from beginning of intervention to discontinuation (1-14 days) | VAS score of tolerance with intervention. 0 = worst possible acceptance 5 = fully acceptance |
| Hspitalization | from hospitalization to release (1-21 days) | duration of hospitalisation ( days) |
| Intervention failure. | from beginning of intervention to discontinuation.(1-14 days) | numbers of intervention failure defined as change of intervention or progression to need for intensive care/ mechanical ventilation. |
Countries
Denmark
Outcome results
None listed