Anesthesia
Conditions
Brief summary
Rocuronium block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. There have been several studies reported positive relationship between muscle mass and amount of neuromuscular junction. The purpose of this study is to find relationship between muscle mass and muscle relaxation time.
Detailed description
Rocuronium block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. There have been several studies reported positive relationship between muscle mass and amount of neuromuscular junction. Until now, dose of rocuronium has been judged by patient's weight and height. However, height and weight do not represent exact muscle mass. The purpose of this study is to find relationship between muscle mass and muscle relaxation time. Measurement of muscle mass will be obtained using bioelectrical impedence analysis.
Interventions
DEVICEInbody
Participant measure muscle mass by bioelectrical impedance analysis (Inbody 720, Seoul, Korea) after fast for eight hours. After measurement, patient is induced anesthesia. Rocuronium dose is 12mg for male, and 9mg for female.
Sponsors
Go Eun Bae
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
19 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* All patient who undergo general anesthesia. * Male; weight 70-75kg , height 170-175cm * Female; weight 53-58kg , height 158-163cm
Exclusion criteria
* Liver and kidney disease * Any types of muscle disorder. * Metal materials or pacemaker in body
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ratio of result of first stimulus(T1) to result of supramaximal stimulation(T0) | two hours | T1 and T0 is obtained by train of four which is commonly used neuromuscular monitoring device. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| completely suppression time of result of first stimulus(T1). | ten minutes | T1 is obtained by train of four which is commonly used neuromuscular monitoring device. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Time until reoccurrence of response of first stimulus(T1). | two hours | T1 is obtained by train of four which is commonly used neuromuscular monitoring device. |
Countries
South Korea
Outcome results
None listed