Healthy Volunteers
Conditions
Brief summary
This research seeks to study the physiological effects of theta-burst transcranial magnetic stimulation (TMS) in the brains of healthy controls using functional MRI and spectroscopy.
Interventions
DEVICEtheta-burst TMS
This protocol involves short periods of pulse delivery in combination with long periods of silent intervals.
DEVICEsham theta-burst TMS
This protocol delivers theta-burst pulses from a sham device (i.e. at same speed and timeframe but without the magnetic output)
Sponsors
Institute of Mental Health Nottingham
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* No personal history of neurological or psychiatric disorders
Exclusion criteria
* Have had a brain injury or neurological disorder * Have ever suffered an epileptic fit * Have any non-removable metal implants * Drink more than 20 units of alcohol per week on a regular basis * Currently take any illicit drugs on regular basis * Likely to be pregnant * Ever suffered from a serious mental illness such as schizophrenia, severe depression or bipolar disorder * Currently take any psychotropic medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in functional connectivity following TMS administration using functional MRI | One hour | Changes in brain connectivity will be assessed by comparing functional MRI scans after theta-burst TMS and sham theta-burst TMS |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in brain metabolites following TMS administration using MR spectroscopy | One hour | Using MRI scans, changes in metabolites in the brain will be assessed following theta-burst TMS and sham TMS |
Countries
United Kingdom
Outcome results
None listed