Diabetes, Hypertension, Sleep
Conditions
Brief summary
This study aims to test the short-term effects of intermittent standing, slow cycling and slow walking, compared to sitting, on continuous blood glucose and ambulatory blood pressure among pre-hypertensive and pre-diabetic adults.
Detailed description
This study will enroll 10 adults who will each complete four experimental conditions in random order. Each of the four experimental conditions are as follows: 1) sit continuously for 8 hours in a simulated office environment, 2) break-up sitting time with standing based on set hourly intervals, 3) break-up sitting time with slow-walking on a treadmill desk based on set hourly intervals, 4) increase energy expenditure by slow cycling based on set hourly intervals. Participants will completed each condition one week apart and dietary intake will be standardized by giving participants the same meals during each intervention condition. Study measures will include: anthropometrics (height and weight), blood pressure, fasting glucose, 24-continuous glucose monitoring, full-day ambulatory blood pressure monitoring, cognitive testing (cognitive performance), energy expenditure, physical activity via accelerometer, sleep via accelerometer, and heart rate.
Interventions
OTHERMaintaining posture and energy expenditure
Participants will sit continuously for 8-hrs during a simulated office environment
OTHERIncreasing energy expenditure
Participants will cycle slowly while seated in prescribed hourly intervals. This condition will increase energy expenditure while keeping a sitting posture
OTHERChanging posture
Participants will transition from sitting to standing in prescribed hourly intervals. This condition will change posture (sit to stand) while maintaining low energy expenditure
OTHERIncreasing energy expenditure and changing posture
Participants will transition from sitting to a walking workstation in prescribed hourly intervals. This condition will both increase energy expenditure and change posture.
Sponsors
Arizona State University
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* pre-hypertensive (systolic blood pressure 120-139 mmHg, or diastolic blood pressure 80-89 mmHg) * impaired fasting glucose (5.6-6.9 mmil/L) * not meeting the physical activity guidelines for adults (\>=150 min/wk of moderate-to-vigorous physical activity)
Exclusion criteria
* smoking, pregnancy, known coronary heart disease, orthopedic limitations for performing physical activity, taking medications to control high blood pressure or high blood glucose, special dietary requirements, and being advised by a doctor to avoid prolonged periods of sitting.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evidence of change in blood pressure following changes in posture and increasing energy expenditure | single-day intervention |
| Evidence of change in blood glucose following changes in posture and increasing energy expenditure | single-day intervention |
Outcome results
None listed