Fragile X Syndrome, Intellectual Disability
Conditions
Brief summary
The purpose of the study is to evaluate a 2-3 day treatment probe targeted to improving social gaze behavior in children with fragile X syndrome (FXS). The investigators will use the principles of Applied Behavior Analysis (ABA) to shape appropriate social skills. Importantly, the investigators propose to examine the effects of this treatment probe on brain and behavior.
Interventions
BEHAVIORALSocial gaze training
Appropriate social gaze behavior will be shaped using the principles of Applied Behavior Analysis.
Sponsors
Stanford University
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
MALE
Age
8 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
1. Boys diagnosed with fragile X syndrome 2. Boys with intellectual disability who do not have FXS or other known genetic disorder associated with intellectual disability 3. Age 8 to 18 years inclusive 4. Ability to travel to Stanford 5. Vineland Adaptive Behavior Scales standard score between 50 and 75 points
Exclusion criteria
1. Sensory impairments, or any other serious medical or neurological condition that affects growth or development (e.g., seizure disorder, diabetes, congenital heart disease). 2. Materials in body that would preclude an MRI scan (e.g., dental braces).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of social gaze aversion recorded during the social challenge | 3 days |
| Heart rate recorded during the social challenge | 3 days |
| Total t-score on the Social Responsiveness Scale (SRS) | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Verbal responses and pauses in conversation observed during the social challenge | 3 days |
| Fractional Amplitude of Low Frequency fluctuations (fALLF) measured in the insular cortex | 3 days |
Countries
United States
Outcome results
None listed