Cardiovascular Diseases
Conditions
Brief summary
The polycystic ovary syndrome (PCOS) is the most common endocrinopathy amongst women of reproductive age. PCOS is associated with various cardiovascular risk factors such as obesity, glucose intolerance, dyslipidemia hypertension and the metabolic syndrome. Whether these increased cardiovascular risk factors result in the development of actual cardiovascular disease in later life remains to be established. Women with premature ovarian insufficiency (POI), experience menopause prior to the age of 40 years. Women with POI may exhibit dyslipidemia. A young age at menopause has been previously associated with increased cardiovascular morbidity and mortality.
Detailed description
Cardiovascular risk profile will be assessed in women with PCOS and POI \> 45 years of age, consisting of: fasting serum and urine analyses blood pressure, length, weight, waist circumference, hip circumference ECG carotid intima media thickness cardiac ultrasound spare serum, plasma and urine will be stored in -80 degrees celsius biobank.
Interventions
PROCEDUREcardiovascular screening
cardiovascular screening: serum, urine, ECG, carotid intima media thickness (IMT), cardiac ultrasound
Sponsors
Amsterdam UMC, location VUmc
Erasmus Medical Center
UMC Utrecht
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
45 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age above 45 years
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| carotid intima media thickness | 10 years post diagnosis | ultrasound measurement of thickness of carotid wall (mean IMT), presence of atherosclerotic plaques (yes/no, location) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| dyslipidemia | 10 years post diagnosis | serum measurement of low density lipoprotein cholesterol, triglycerides, total cholesterol, high density lipoprotein cholesterol |
| insulin and glucose levels | 10 years post diagnosis | — |
| homocysteine | 10 years post diagnosis | — |
| C-reactive protein | 10 years post diagnosis | — |
| androgen levels | 10 years post diagnosis | — |
| electrocardiogram (ECG) | 10 years post diagnosis | documentation of heart rythm, potential signs of ischemia (ST segment), length PR, QRS, QT, RR interval |
| cardiac ultrasound (hypertrophy) | 10 years post diagnosis | measurement of left ventricular ejection fraction and left ventricular mass, |
| uric acid | 10 years post diagnosis | — |
Countries
Netherlands
Outcome results
None listed