A Single-Center, Exploratory Study to Analyze the Dynamics of Skin Microflora Following Exposure to Surfactants

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02615912

Enrollment

Registered

2015-11-26

Start date

2015-11-30

Completion date

2016-02-29

Last updated

2016-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dermatitis

Brief summary

The purpose of this study is to understand the changes in skin microflora, skin barrier function, and skin biochemical constituents in response to direct contact with model surfactants used in personal care articles. The results from this study will provide insights into the complex interaction between the skin microbiome and the epidermis after exposure to surfactants.

Interventions

OTHERPEG-40 Hydrogenated Castor Oil (Tagat CH40, Evonik) 1.5%

OTHERLauryl glucoside (Plantacare® 1200UP, BASF) 1.5%

OTHERSorbitan palmitate (SPANTM 40 (powder), Croda) 1.5%

OTHERSilwet* DA-63 (Momentive) 1.5%

OTHERSodium lauryl sulfate (Sigma Aldrich) 1.0%

OTHERWater (control)

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy Subjects with Fitzpatrick Skin Types I, II or III

Exclusion criteria

* Subjects with visible skin disease, tattoos, skin condition, or abnormal skin color

Design outcomes

Primary

Measure	Time frame	Description
Amount of microbes present on skin after exposure to various surfactants	4 days	—
Type of microbes present on skin after exposure to various surfactants	4 days	Microbes will be identified by metagenomic sequencing

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026