Colorectal Liver Metastases
Conditions
Keywords
NK-cells, T-cells
Brief summary
The long-term outcome of patients resected for colorectal liver metastases (CLM) after neoadjuvant chemotherapy (CHT) depends by several tumoral and non-tumoral factors, such as the immune response to the tumor and to the CHT. The aim of this study was to investigate the impact of the pathological and immunological response in patients undergoing liver resection for CLM after CHT in regards to the long-term outcome.
Detailed description
The immunoreactivity to CD3+ and NKp46+ cells inside the tumor, at the border between the tumor and the normal liver, and inside the normal liver will be tested by computer-assisted image analyses in patients undergoing liver resection for CLM between 2005 and 2013 preoperatively treated with oxaliplatin or irinotecan with or without bevacizumab or cetuximab. The survival will be assessed in relation to several prognostic factors and to that immunoreactivity.
Interventions
PROCEDUREHepatic resection
Removal of a part of the liver during surgery
Sponsors
University of Milan
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* histological proven colorectal liver metastases * complete clinical, surgical, pathological and follow-up data
Exclusion criteria
* non-radical surgery * incomplete clinical, surgical, pathological and follow-up data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival | 5 years |
Countries
Italy
Outcome results
None listed