Cardiovascular Diseases, Metabolic Syndrome X
Conditions
Keywords
Metabolic Syndrome X, Overweight, Waist Circumference, Blood Pressure, Cholesterol, Oat beta glucan
Brief summary
The purpose of this study is to determine whether daily consumption of soluble fibre, oat beta glucan (4g), for six weeks will have any impact on overweight/obese individuals in terms of risk factors used to define metabolic disease.
Detailed description
The purpose of this study is to determine whether daily consumption oat beta glucan (4g) for six weeks will have any impact on overweight/obese individuals in terms of risk factors used to define metabolic disease. Oat beta-glucan has been incorporated into a novel oatcake product manufactured by Nairn's Oatcakes Ltd. Consumption of the oatcake products will deliver enough oat-beta glucan to the diet to meet European Food Safety Authority health claims for lowering blood cholesterol and reducing post-prandial glycaemic responses.
Interventions
DIETARY_SUPPLEMENTBeta-glucan enriched oatcake
5 oatcakes enriched with oat beta-glucan will be consumed daily for six weeks
DIETARY_SUPPLEMENTIsocaloric control
6.5 wheat based control snacks without beta-glucan will be consumed daily for six weeks
Sponsors
Queen Margaret University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Males and females 18 years and older * Waist circumference measurements of ≥94cm for males and 80cm for females, or a body mass index of ≥30kg/m2 * Individuals who are able to provide informed consent
Exclusion criteria
* Postmenopausal females * Smokers * Individuals who suffer from, or taking medication for, cardiovascular or gastro-intestinal disease * Impaired glucose tolerance/Diabetes mellitus * Pregnancy or breastfeeding * Those who have high dietary fibre intakes (\>20g/day) * Known food allergies to oats, wheat, lactose, or sesame seeds
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Waist Circumference | 6 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Fasting Serum Triglycerides | 6 weeks |
| Oral Glucose Tolerance Test | 6 weeks |
| Fasting Serum HDL Cholesterol | 6 Weeks |
| Blood Pressure | 6 Weeks |
| Interleukin-6 | 6 weeks |
| Energy Intakes (kilocalories) and Macronutrient intakes (grams) from food diaries | 6 weeks |
| Fasting Serum total Cholesterol | 6 weeks |
Countries
United Kingdom
Outcome results
None listed