Characterization of Phenotype and Genotype of Early Onset Enteropathies

Host-Microbiota Interactions Across the Gut Immune System: Characterization of Phenotype and Genotype of Early Onset Enteropathies

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02614911

Acronym

IMMUNOBIOTA

Enrollment

1445

Registered

2015-11-25

Start date

2014-06-16

Completion date

2054-06-15

Last updated

2025-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Bowel Disease

Keywords

Early Onset Entheropathy

Brief summary

This study has been set up in order to characterize phenotypes and genotypes of patients with early onset enteropathies. In that goal, Investigators will collect biological samples (mainly blood) of patients suffering from early onset enteropathies and their healthy relatives.

Detailed description

This study specifically aims at the genetic analysis of early onset enteropathies with the goal in mind to delineate human pathways necessary to maintain intestinal homeostasis despite the considerable density of microbes colonizing the distal part of the human intestine.

Interventions

OTHERBiological sampling

Biological sampling including blood, feces, biopsies...

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

Main Inclusion Criteria: * Severe chronic enteropathy * Patients developing their first symptoms within the first 6 years of life and, in priority within the first two years of life, or patients with a disease of later onset, in case of a familial history suggestive of inherited mutations notably in families comprising several affected members * OR : Be a patient's relative, even if presenting with enteropathy of later onset. Main

Exclusion criteria

* Subject having participated to any therapeutical clinical study in the 30 days preceding the inclusion in this study,

Design outcomes

Primary

Measure	Time frame	Description
Increasing the current rate (20%) of genetic characterization of early onset entheropathies	40 years	Currently, around 20% of early onset entheropathies are genetically characterized. Investigators want to increase this rate via this research protocol. Our long term objective is to characterize phenotypes and genotypes of patients with early onset enteropathies.

Countries

France

Contacts

Primary ContactNadine Cerf-Bensussan

nadine.cerf-bensussan@inserm.fr+ 33 1 42 75 42 88

Backup ContactFabienne Charbit-Henrion

fabienne.charbit-henrion@inserm.fr+33 1 42 75 42 45

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026