Coughing Response, Thyroid Surgery, General Anesthesia
Conditions
Keywords
Dexmedetomidine, Coughing Response, Postoperative Recovery Quality, Thyroid Surgery
Brief summary
Coughing is a common adverse reaction of thyroid surgery,which could result in postoperative bleeding.Postoperative bleeding is a serious and potentially life-threatening complication，which could result in acute upper airway obstruction due to neck hematoma and increase the need for re-operation.The purpose of this study is to investigate whether dexmedetomidine can reduce the incidence of postoperative coughing and contribute to postoperative recovery in patients undergoing tyroid surgery with general anesthesia.
Detailed description
Thyroid surgery is a common clinical surgery,the incidence of postoperative coughing is up to 32.4%.Coughing response could result in postoperative bleeding,even cause respiratory tract obstruction,affect patients' postoperative recovery .Dexmedetomidine,an α2 adrenergic agonist,has hypnotic,analgesic, anxiolytic,antisympathetic effects,which could facilitate the sedation of patients while maintaining their consciousness and keep respiration and circulation stable .For these benefits,dexmedetomidine was widely used for general anesthesia.However,whether dexmedetomidine can reduce the incidence of postoperative coughing is unclear.Therefore,the investigators conduct this randomized controlled double-blind trial,to investigate the effects of dexmedetomidine on coughing and postoperative recovery quality in patients undergoing tyroid surgery with general anesthesia.
Interventions
DRUGDexmeditomidine
Dexmeditomidine 0.2 ug/kg·h will be administered to participants by intravenous infusion at the beginning of the surgery,and continued till end of surgery.
DRUGnormal saline
Isovolumetric normal saline will be administered to participants by intravenous infusion at the beginning of the surgery,and continued till end of surgery.
Sponsors
First Affiliated Hospital of Chongqing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
1. Aged from 18 to 65 years old 2. American Society of Anesthesiologists (ASA) physical statusⅠor Ⅱ 3. Diagnosed by B ultrasonic or tissue biopsy show that patients thyrophyma,thyroid cancer,thyroid nodule,etc,who need to accept thyroid surgery
Exclusion criteria
1. large goiter or hyperthyroidism 2. Preoperative coughing caused by primary diseases of patients 3. Ⅱdegrees above atrioventricular block 4. Allergy to anesthesia 5. History of diabetes 6. Pregnant women 7. Serious mental disease 8. History of alcohol or drug abuse 9. Severe heart renal or liver dysfunction 10. The presence of an upper respiratory infection 11. Asthma 12. Anticipated difficult airway
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the incidence of coughing | within 48 hours postoperatively | coughing will be observed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| coughing on a four-point scale | within 48 hours postoperatively | coughing on a four-point scale will be measured within 48 hours postoperatively |
| the eyes opening time | within 48 hours postoperatively | the eyes opening time will be observed |
| the time of extubation | within 48 hours postoperatively | the time of extubation will be recorded |
| visual analogue scale (VAS) | at 30 minutes after extubation | visual analogue scale will be measured at 30 minutes after extubation |
| sedation-agitation scale(SAS) | at 30 minutes after extubation | sedation-agitation scale will be measured at 30 minutes after extubation |
Countries
China
Contacts
Primary ContactYanping Zhang, Master
Outcome results
None listed