Septic Shock
Conditions
Keywords
septic shock, sedation, microcirculation
Brief summary
The investigators will conduct a prospective, single-center, randomized, double-blinded, controlled study to investigate the effect of early goal directed sedation on microcirculation in early septic shock patients.
Detailed description
Recent studies suggest that early goal directed sedation might improve the outcome of critically ill patients. The investigators will conduct a prospective, single-center, randomized, double-blinded, controlled study to investigate the effect of early goal directed sedation on microcirculation in early septic shock patients with relative stable hemodynamics.
Interventions
DRUGDexmedetomidine for sedation
Dexmedetomidine or control drug for sedation * Analgesia * Propofol at lowest dosage. * Dose range: 0.1- 0.7 u/kg/hour * Target RASS score of -2 to +1 * Supplemental other sedatives at lowest effective dose
Sponsors
Southeast University, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Septic shock patients despite early goal directed therapy * Required sedation
Exclusion criteria
* Age\< 18 * Pregnancy * Bradycardia (HR\<55bpm) * Systolic blood pressure \< 80 mmHg / mean arterial pressure \< 50 mmHg on maximal support * Death imminent * Unlikely to survive 90 days * Acute liver failure * Dementia * High-grade block in the absence of a functioning pacemaker.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microcirculatory function as assessed by perfused vessel density | one hour | Microcirculatory parameter |
Secondary
| Measure | Time frame |
|---|---|
| Dose of sedatives and analgesic agents | 14 days |
| Oxygen metabolic: lactate clearance time | six hours |
Countries
China
Contacts
Primary ContactJingyuan Xu, M.D.
Outcome results
None listed