Pediatric Oncology
Conditions
Brief summary
The purpose of this study is to determine whether combined endurance and resistance training can improve muscle strength in children and adolescents with cancer during the intensive treatment phase.
Interventions
BEHAVIORALExercise Training
Exercise training during intensive medical treatment. Training mainly composed of endurance and resistance exercises. 3 to 5 times per week for six weeks.
Sponsors
Johannes Gutenberg University Mainz
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
4 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Malignant Tumor * Medical Treatment in the Center for Pediatrics, Hematology, Oncology and Hemostaseology Mainz (Germany) * \> 3 years * Signed Informed Consent
Exclusion criteria
* Functional and/or cognitive limitations which limit performance during training * Orthopedic condition which hinders to adequately participate in exercise training * Heart failure (NYHA III-IV) * Partial or global respiratory failure * Symptomatic coronary disease * Serious therapy-refractory hypertonia * Sustainable thrombocytopenia \<10.000/µl, f. ex. therapy-refractory autoimmune thrombocytopenia * Hereditary or acquired thrombocytopenia or coagulation disturbance * Uncontrolled cerebral spasm * CNS metastases * Medical or psychological condition which does in the doctors opinion not allow participation in sport activity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle strength: lower limb | Six weeks (pre-post intervention) | Lower limb muscle strength measured by the load (kg) sustained in one repetition maximum test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Biomarker in Blood | At the beginning of the intervention and three and six weeks after the beginning. Comparing the two time points inbetween study groups | Immune status and metabolic status |
| Body composition | Six weeks (pre-post intervention) | Bioelectrical Impedance Analysis |
| Six-minute-walk performance | Six weeks (pre-post intervention) | — |
| Muscle strength: upper limb | Six weeks (pre-post intervention) | Upper limb muscle strength measured by the load (kg) sustained in one repetition maximum test |
| Quality of Life | Six weeks (pre-post intervention) | KINDL: health related quality of life questionnaire |
| Cardiorespiratory performance | Six weeks (pre-post intervention) | Ergospirometry |
| Fatigue | six weeks (pre-post intervention) | Pediatric Quality of Life Inventory (PedsQL) Multidimensional Fatigue Scale |
Countries
Germany
Outcome results
None listed