Hypotension
Conditions
Brief summary
The purpose of this study is to explore the neurohumoral mechanism of deferent frequency TEAS pretreatment.
Detailed description
Patients were randomly assigned to three groups, receiving TEAS 30min before anesthesia. The frequency of high frequency group is set to 10/50HZ, low frequency group is 2/10HZ, and the fake stimulation group only attach electrodes without electric current. Acupoint selection is bilateral Neiguan points(PC6). Venous blood is collected 4ml before and immediately after TEAS respectively. Heart rate variability is monitored continuously during the 30min TEAS. The adverse events recorded.
Interventions
2/10HZ Electric stimulation was given through electrode attached to specific acupoints
DEVICEfake stimulation
Patients were only attached electrodes without electric current
Sponsors
wangqiang
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 18yrs-65yrs * ASA 1-2 * Scheduled for elective operation under general anesthesia * BMI 18-30kg/m2 * Informed consented
Exclusion criteria
* Contraindications to TEAS * Communication difficulty with researchers * Addicted to alcohol, analgesics or other drugs * Cardiac insufficiency or high blood pressure without controlled * Hepatic or renal dysfunction * Participate in the other clinical trial 3 month before the enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration of epinephrine(ng/L) | change of TEAS 0 and 30 minutes |
| Plasma concentration of norepinephrine(ng/L) | change of TEAS 0 and 30 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate variability | During 30min TEAS |
| plasma concentration of renin(ng/L) | change of TEAS 0 and 30 minutes |
| plasma concentration of aldosterone(ng/L) | change of TEAS 0 and 30 minutes |
| plasma concentration of glucocorticoid(μg/L) | change of TEAS 0 and 30 minutes |
| plasma concentration of β-endorphin(ng/L) | change of TEAS 0 and 30 minutes |
Contacts
Primary ContactQiang Wang
Outcome results
None listed