Elimination of Antibiotics During Renal Replacement Therapy and Cytosorb Adsorptive Therapy

Elimination of Antibiotics During Combined Continuous Renal Replacement Therapy and Cytosorb Adsorptive Therapy in Patients With Sepsis and Acute Kidney Injury

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02611271

Enrollment

Registered

2015-11-20

Start date

2017-12-01

Completion date

2020-12-31

Last updated

2020-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Critical Illness, Sepsis

Brief summary

Cytokine adsorption using the cytosorb adsorber is currently investigated to reduce the levels of proinflammatory cytokines in patients with severe sepsis and septic shock. The adsorber is frequently used in series with continuous renal replacement therapy. Up to date, no data on the removal of antibiotic drugs during combined renal replacement therapy and cytokine adsorptive therapy is available. Therefore, we want to investigate \- whether and to what extent antibiotic drugs (piperacillin/tazobactam and imipenem/cilastatin) are removed during combined continuous renal replacement therapy and cytosorb adsorption in patients with severe sepsis and septic shock

Detailed description

Patients in this trial are undergoing renal replacement therapy as part of their routine care. Thus, this is an observational trial.

Interventions

OTHERMonitoring of antibiotic drug removal

No study specific intervention will be performed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Intensive care patients with severe sepsis or septic shock and acute kidney injury requiring continuous renal replacement therapy and cytokine adsorption * Age \> 18 y

Exclusion criteria

* \< 18 y * Pregnancy * Contraindications against citrate-anticoagulation or continuous renal replacement therapy or cytokine adsorption

Design outcomes

Primary

Measure	Time frame	Description
Removal of antibiotic drugs during the first 8 hours of combined continuous renal replacement therapy and cytosorb adsorption	8 hours	Removal of antibiotic drugs during combined CRRT and adsorption will be evaluated by calculating total filter clearance using the drug concentration pre- and postfilter as well as the dialysate concentration. The adsorptive clearance will be evaluated using the pre- and postadsorber concentration. The outcome measure will be removal of antibiotic drug \[mg/8 h dosing interval\].

Countries

Germany

Contacts

Primary ContactDetlef Kindgen-Milles, Prof.

Kindgen-Milles@med.uni-duesseldorf.de+49 211 81

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026