Idiopathic Membranous Nephropathy
Conditions
Keywords
Idiopathic Membranous Nephropathy, Jianpiyiqi Recipe, Huoxuejiedu Recipe, Effectiveness, Safety
Brief summary
To evaluate the effectiveness and safety of the Chinese medicine treatment for multiple drug resistance of MN patients with Jianpiyiqi and Huoxuejiedu Recipe.
Detailed description
Based on previous research, the investigators hoping to identity the standard treatment program for MDR IMN patients with high treatment difficulty, TCM syndrome of s Pixushuifan. Subsequently, to evaluate the effectiveness and safety of the Chinese medicine treatment for multiple drug resistance of MN patients with Jianpiyiqi and Huoxuejiedu Recipe. With twenty national-grade III hospital of to formed TCM Comprehensive treatment plan and to evaluate the effectiveness and safety of the Chinese medicine treatment for multiple drug resistance of MN patients with Jianpiyiqi and Huoxuejiedu Recipe. Furthermore, search for potential diagnostic predictor in IMN by Proteomics and Metabolomics. The investigators purpose is improve the clinical remission rate of MN, further establish the treatment of TCM in the treatment of MN.
Interventions
DRUGJianpixiaozhong particles and Wuse Dietotherapy
Jianpixiaozhong particles: Three packs once,bid po; Wuse Dietotherapy: one packs once,bid po
Sponsors
Fudan University
Ruijin Hospital
Shanghai 6th People's Hospital
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Changhai Hospital
Shanghai Putuo District Center Hospital
ShuGuang Hospital
Shanghai Yueyang Integrated Medicine Hospital
Shanghai Changzheng Hospital
Shanghai Minhang Central Hospital
Zhujiang Hospital
Guangxi Traditional Chinese Medical University
Huashan Hospital
The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Xinqiao Hospital of Chongqing
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Nanjing University of Traditional Chinese Medicine
Tongji Hospital
Chinese Academy of Sciences
RenJi Hospital
Shanghai University of Traditional Chinese Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Age 18-75 years; 2. Gender, nationality; 3. Pixushuifan syndrome, IMN confirmed by renal biopsy and clinical examination; 4. Treatment invalided by two or more than two kinds of Hormone or immunosuppressive agents ; 5. CKD phase 1-3（eGFR（EPI Formula）≥30ml/min/1.73m2）
Exclusion criteria
1. Progressive MN (progressive renal impairment, renal biopsy confirmed Necrotic Vasculitis and Large crescent formation\>50%), combined with IgA nephropathy, diabetic nephropathy and other renal diseases; 2. Anti-nuclear antibodies, double stranded DNA, ANCA or other indicators of immune disorders; 3. Active hepatitis B and liver function test sustained abnormal; 4. Patients with malignant tumor or have a history of cancer, HIV infection, history of mental illness, acute central nervous system diseases, severe gastrointestinal diseases; 5. Merger with other serious disease and dysfunction of the organ; 6. Gravid or lactation woman; 7. Other clinical trials are being studied.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remission rate of 24 hours urinary protein quantitative | two weeks to three months |
Secondary
| Measure | Time frame |
|---|---|
| Renal function, glomerular filtration rate (EPI formula), Plasma albumin | two weeks to three months |
| Blood lipid | half a year |
| Change of TCM Syndrome | two weeks to three months |
Countries
China
Contacts
Primary ContactYueyi Deng, MD.
Backup ContactWanjia Chen, MS.
Outcome results
None listed