The Different Analgesic Potency of Volatile Anesthetics at Equi-MAC

The Different Analgesic Potency of Sevoflurane and Desflurane at Equi-minimum Alveolar Concentration

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02609802

Enrollment

Registered

2015-11-20

Start date

2015-11-30

Completion date

2016-07-28

Last updated

2017-11-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopedic Disorders

Brief summary

The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Detailed description

Volatile anesthetics vary in their relative hypnotic potencies. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetics produced different EEG-derived indices such as bispectral index. However, there was no controlled study that demonstrates the difference of analgesic potency. The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Interventions

DRUGSevoflurane

Anesthesia was maintained with sevoflurane in patients undergoing arthroscopic shoulder surgery under general anesthesia and interscalene brachial plexus block.

DRUGDesflurane

Anesthesia was maintained with desflurane in patients undergoing arthroscopic shoulder surgery under general anesthesia and interscalene brachial plexus block.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

19 Years to 65 Years

Healthy volunteers

Inclusion criteria

* patients undergoing arthroscopic shoulder surgery * patients with american society of anesthesiologist physical status I, II * patients aged 19-65 years * patients obtaining written informed consent

Exclusion criteria

* patients with a history of any psychiatric or neurological disease * patients who had received any medication affecting the central nervous system * patients who had received medication affecting the sympathetic or parasympathetic nervous systems * patients who have not received interscalene approach brachial plexus block (refusal or failure) * pregnant women

Design outcomes

Primary

Measure	Time frame	Description
Analgesic potency of volatile anesthetics	the first 60 min of maintaining a steady state 1 MAC of volatile agents	The analgesic potency was evaluated by surgical pleth index value

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026