Acute Respiratory Failure
Conditions
Keywords
Acute Respiratory Failure, ARDS, ECMO, Lung transplantation, Acid-Base Equilibrium
Brief summary
Crystalloid solutions modify acid-base equilibrium according to their electrolyte composition. Moreover, it has been suggested that these alterations are generated by the difference between the solution strong ion difference (SID) and the plasma bicarbonate level. An increased risk of acute kidney injury and renal replacement therapy has been associated to the infusion of chloride rich crystalloids. This study aims to compare, in patients with acute respiratory failure undergoing ECMO support, the effects on acid-base status and renal function of crystalloids commonly employed for circuit priming to a balanced solution created with a SID equal to patients' bicarbonate level.
Interventions
OTHERPriming of ECMO circuit with 0.9% NaCl
0.9% NaCl as priming crystalloid solution
OTHERPriming of ECMO circuit with Ringer Lactate
Ringer Lactate as priming crystalloid solution
OTHERPriming of ECMO circuit with Balanced Solution
Balanced Solution as priming crystalloid solution
Sponsors
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with Acute Respiratory Failure in need for ECMO treatment
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variation in Acid-Base Equilibrium (Base Excess) | First 24 hours after ECMO start |
Secondary
| Measure | Time frame |
|---|---|
| Variation in Acid-Base Equilibrium (pH) | First 24 hours after ECMO start |
| Variation in Renal Function | First 24 hours after ECMO start |
Countries
Italy
Contacts
Primary ContactPietro Caironi, MD
Outcome results
None listed