Furcation Defects
Conditions
Brief summary
The present study was designed to evaluate the combined efficacy of PRF and 1% ALN in the treatment of mandibular degree II furcation defects when compared with PRF and open flap debridement (OFD) alone.
Detailed description
Background: Various regenerative materials have been introduced and tested in the treatment of furcation defects. Platelet-rich fibrin (PRF) is a reservoir of growth factors and cytokines which are the key factors for regeneration of bone and maturation of the soft tissue. Alendronate (ALN), a potent member of bisphosphonate group is known to promote tissue regeneration by inhibiting osteoclastic bone resorption and promoting osteoblastogenesis. The present study was designed to evaluate the combined efficacy of PRF and 1% ALN in the treatment of mandibular degree II furcation defects when compared with PRF and open flap debridement (OFD) alone. Methods: Seventy two mandibular furcation defects were treated with either OFD alone (Group 1), OFD with PRF (Group 2), and OFD with PRF+1% ALN (Group 3). Clinical parameters; site specific plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD), relative vertical attachment level (RVAL) and relative horizontal attachment level (RHAL), intrabony defect depth (IBD) were recorded at baseline before surgery and 9 months post-operatively. Percentage radiographic defect fill was evaluated at baseline and 9 months.
Interventions
PROCEDUREOpen flap debridement (OFD)
Open flap debridement (OFD) alone
PROCEDUREOFD with Platelet rich fibrin (PRF)
Open flap debridement (OFD) with Platelet rich fibrin (PRF) placement
PROCEDUREOFD with Platelet rich fibrin (PRF)+1% Alendronate (Drug) in gel form
Open flap debridement (OFD) with Platelet rich fibrin (PRF)+1% Alendronate gel placement
Sponsors
Government Dental College and Research Institute, Bangalore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Presence of buccal Class II furcation defects in endodontically vital, asymptomatic mandibular first and second molars with a radiolucency in the furcation area on an intraoral periapical radiograph with probing depth (PD) ≥ 5mm and horizontal ≥ PD 3mm after phase I therapy i.e, scaling and root planing (SRP); * No history of antibiotic or periodontal therapy in the preceding 6 months.
Exclusion criteria
* Systemic conditions known to affect the periodontal status; * Medications known to affect the outcomes of periodontal therapy; * Hematological disorders and insufficient platelet count (\<200,000/mm3); * Pregnancy/lactation; * Smoking and tobacco use in any form * Immunocompromised individuals; * Those having unacceptable oral hygiene (plaque index \[PI\] \>1.5). * Teeth with furcation involvement, non-vital teeth, and carious teeth indicated for restorations and mobility of at least grade II * Aggressive periodontitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiographic bone fill | baseline to 9 months | assessed in percentage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| probing depth | baseline to 9 months | measured in mm |
| Relative vertical attachment level | baseline to 9 months | measured in mm |
| Relative horizontal attachment level | baseline to 9 months | measured in mm |
| modified sulcus bleeding index | baseline to 9 months | 0-3 scale |
| plaque index | baseline to 9 months | 0-3 scale |
Countries
India
Outcome results
None listed