Lung Neoplasms, Meningeal Carcinomatosis
Conditions
Keywords
lung cancer, leptomeningeal metastases, cell-free DNA
Brief summary
The primary purpose of this study is to compare the positive rate between the cell-free DNA and cytological examination of cerebrospinal fluid in Advanced lung cancer with leptomeningeal metastases.
Interventions
None listed
Sponsors
Sun Yat-sen University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Patient who was confirmed primary lung cancer by pathologic histology or cytology 2. Adult patients (≥18 years and ≤75 years). ECOG Performance Status 0 or 1.Life expectancy of at least 12 weeks. 3. Clinical symptoms and imaging tests are highly suspicious of advanced lung cancer with leptomeningeal metastases 4. Without contraindications to lumbar puncture
Exclusion criteria
1. Patients who have primary benign or malignant brain tumor and metastatic malignant brain tumor 2. Patients who have contraindications to lumbar puncture 3. Serious uncontrolled systemic disease including active infection,uncontrolled hypertension,diabetes,unstable angina,congestive heart failure,myocardial infarction,severe arrhythmia which needs drugs,hepatic、renal and metabolic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| positive rate between the cell-free DNA and cytological examination of cerebrospinal fluid | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| The relationship between the number of cell-free DNA and OS | 2 years |
Countries
China
Contacts
Primary Contactli-kun chen, Doctor
Outcome results
None listed