Outcomes of Severe Osteoporotic Fractures Hospitalized in France: the CROSS Cohort

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02606162

Acronym

CROSS

Enrollment

912

Registered

2015-11-17

Start date

2016-06-08

Completion date

2025-01-08

Last updated

2026-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe Fragility Fracture

Brief summary

The purpose of this study is to determine the outcomes of severe osteoporotic fractures hospitalized in France, the risk of incident severe fracture at 2 years and 5 years and the risk of mortality over 2 and 5 years.

Detailed description

In France, the burden of osteoporotic fractures has been studied using cross sectional data from the French hospital national database. The availability of fracture liaison service in the main French cities allows the recruitment of a high number of these targeted patients. A large national multicenter, longitudinal, prospective cohort of patients hospitalized for severe osteoporotic fracture, the CROSS cohort ("Cohorte sur les Risques d'une OStéoporose Sévère"), in order to update data on prognosis (refracture, mortality), epidemiology and of severe osteoporotic fractures.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* Men and women aged above 60 years, living in France and hospitalized for severe fragility fractures in response to low-energy trauma (e.g., a fall from standing height). * Vertebral fractures have to be confirmed by an X ray examination. * To be eligible for the study the patient has to be included and interviewed within 12 weeks of the fracture event's diagnosis. Note : patients in guardianship or curatorship can be included in this protocol. * Informed and free consent given and form signed and dated

Exclusion criteria

* Non severe fracture (for example wrist fracture), pathological fractures, high trauma fractures and per prosthetic fractures. * Non registration with a social security scheme (holder or beneficiary).

Design outcomes

Primary

Measure	Time frame	Description
Number of new severe fracture over 2 years	2 years	To assess the incidence of new severe fracture over 2 years in patients hospitalized for a severe fracture

Secondary

Measure	Time frame	Description
Number of new severe fracture over 5 years	5 years	To assess the incidence of new severe fracture over 5 years in patients hospitalized for a severe fracture

Countries

France

Contacts

PRINCIPAL_INVESTIGATORKarine BRIOT, MD, PhD

Assistance Publique - Hôpitaux de Paris

Outcome results