Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02604095

Enrollment

Registered

2015-11-13

Start date

2014-05-31

Completion date

2015-10-31

Last updated

2015-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acanthosis Nigricans, Obesity

Keywords

Acanthosis nigricans, Obesity

Brief summary

Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism.

Detailed description

The effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism in patient with obesity and acanthuses nigrican.

Interventions

DIETARY_SUPPLEMENTmelatonin

Take one tablet (containing melatonin 3mg, calcium 52mg, vitamin B6 5mg) at bedtime everyday for 12 weeks.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Age:18-60 years old; * BMI ≥ 28 kg/m2； * With acanthosis nigricans。

Exclusion criteria

* With liver, kidney, gastrointestinal or other major organic serious diseases, cancer, lactating women, pregnancy.

Design outcomes

Primary

Measure	Time frame	Description
insulin resistance index	12 weeks	HOMA-IR:serum fasting insulin(mmol/L) × serum fasting glucose(mmol/L)/22.5

Secondary

Measure	Time frame	Description
Body weight	12 weeks	Body weight (kg)
Body fat	12 weeks	Body fat (%)
Neck circumference	12 weeks	Neck circumference (cm)
Waist circumference	12 weeks	Waist circumference (cm)
Blood pressure	12 weeks	Systolic blood pressure (mmHg) and diastolic blood pressure (mmHg)
Triglyceride	12 weeks	Triglyceride (mmol/L)
Low Density Lipoprotein	12 weeks	Low Density Lipoprotein (mmol/L)
High Density Lipoprotein	12 weeks	High Density Lipoprotein (mmol/L)
Total Cholesterol	12 weeks	Total Cholesterol (mmol/L)

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026