Mucociliary Clearance Defect, Physical Disability
Conditions
Brief summary
Randomized clinical trial, conducted in the Intensive Care Unit of the Hospital de Clinicas de Porto Alegre from october 2011 until november 2015 .
Detailed description
Objective: To compare the effectiveness of techniques: vibrocompression (G1), hyperinflation with mechanical ventilation (G2) vibrocompression + hyperinflation with mechanical ventilation (G3) in the amount of aspirated secretions, mechanical ventilator time, incidence of ventilator-associated pneumonia , reintubation tracheal and mortality in mechanical ventilator. Primary outcome: weight in grams of the aspirated secretions. Secondary outcome: hemodynamic and pulmonary parameters: heart rate, respiratory rate, mean arterial pressure, peripheral arterial oxygen saturation; peak inspiratory pressure, tidal volume; dynamic compliance ; mechanical ventilator time; reintubation tracheal; Incidence of ventilator-associated pneumonia and mortality in mechanical ventilator.
Interventions
OTHERVibrocompression (VB)
Vibrocompression is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation (MV)
OTHERHyperinflation (HMV)
Hyperinflation technique with mechanical ventilator which aims to clear the airways of patients on mechanical ventilation
OTHERHMV+VB
Association between Vibrocompression and Hyperinflation with mechanical ventilator
Sponsors
Hospital de Clinicas de Porto Alegre
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* In mechanical ventilation for a period of 24-72 h * End-expiratory pressure (PEEP) lower 10 cm of water. * Lower noradrenaline doses of 0.5mg / kg / minute for an average greater than or equal blood outstrips 60 mmHg.
Exclusion criteria
* Pneumothorax and hemothorax undrained * Subcutaneous emphysema * Osteoporosis * Acute respiratory distress syndrome - (ARDS) * Fractures of ribs * Obese ( BMI greater than 35) * Mechanical ventilator with higher peak pressures 40 cm of water.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight in grams of the pulmonary secretions | up to 24 weeks. |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of ventilator-associated pneumonia in percentage | Through study completion, an average of 3 years. |
| Mortality in the MV in percentage | Through study completion, an average of 3 years. |
| Heart Rate | up to 24 weeks. |
| Respiratory frequency | up to 24 weeks |
| Reintubation tracheal in percentage in the last 24 hours | Through study completion, an average of 3 years. |
| Time mechanical ventilator (MV) in days | Through study completion, an average of 3 years. |
| Tidal volume in milliliters | up to 24 weeks |
| Peak inspiratory pressure in centimeters of water | up to 24 weeks |
| Peripheral oxygen saturation in percentage | up to 24 weeks |
Outcome results
None listed