Hyperprolactinemia, Spontaneous Intracranial Hypotension
Conditions
Brief summary
Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns. Typical magnetic resonance imaging findings include subdural fluid collections, enhancement of pachymenginges, engorgement of venous structures, pituitary hyperemia, and sagging of the brain (SEEPS). Because pituitary hyperemia has been documented in cases of spontaneous cerebral spinal fluid leakage and is known to mimic a pituitary tumor or hyperplasia, the investigators would like to like to assess the clinical manifestations and neuroimaging abnormalities of SIH patients with regard to the pituitary gland. Specifically, the investigators are looking to analyze the compression of the pituitary stalk and conduct a systemic evaluation of pituitary function in SIH patients.
Interventions
OTHERPituitary panel will be drawn pre-op and post-op for all patients.
Sponsors
Cedars-Sinai Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female patients * Age 18 years and older * Diagnosis of SIH: * LP * Brain MRI (SEEPS)
Exclusion criteria
* Pregnant and post-partum females * Nursing mothers * Patients with potential hyperprolactinemia due to: * Hypothyroidism, * Chronic renal disorder * Liver disease (including cirrhosis) * Primary or secondary amenorrhea * Polycystic Ovary Syndrome * Seizure disorder * Illicit drug use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparing the levels of prolactin pre and post treatment | 90 days |
Countries
United States
Outcome results
None listed