Nephrostomy; Complications, Observation of Neuromuscular Block, Pneumoperitoneum
Conditions
Brief summary
Live kidney transplantation is first choice for patients with end-stage kidney disease. Therefore, the safety and well-being of kidneys donors are highly important objectives in live kidney donation. Low pressure pneumoperitoneum can decrease postoperative pain and therefore also concomitant use of opioids.
Detailed description
However low pressure pneumoperitoneum can also decrease peri-operative conditions. In this trial the researchers will investigate whether peri-operative conditions during low pressure pneumoperitoneum can be optimized by the use of deep neuromuscular block.
Interventions
OTHERDeep neuromsucular block
Deep or standard neuromuscular block
Sponsors
Leiden University Medical Center
Radboud University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* obtained informed consent * age over 18 years
Exclusion criteria
* chronic use of analgesics or psychotropic drugs * use of non-steroidal anti-inflammatory drugs shorter than 5 days before surgery * known or suspect allergy to rocuronium or sugammadex * significant liver or renal dysfunction * pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean surgical rating score | perioperative |
Secondary
| Measure | Time frame |
|---|---|
| Conversion to standard pressure pneumoperitoneum | perioperative |
| Intra-operative complications | perioperative |
| Length of pneumoperitoneum | perioperative |
Countries
Netherlands
Outcome results
None listed