Heart Transplantation
Conditions
Keywords
exercise test, biological markers
Brief summary
High intensity Interval training (HIT) has repeatedly been documented to have superior positive effects on oxygen uptake and general physical health compared to continuous moderate exercise in healthy individuals and patients with heart disease. Recently, the same effect has been shown in heart transplanted recipients. Which mechanisms that explains this difference is uncertain; the effect can be due to changes in the heart or changes in the peripheral tissue and muscles. To explore these mechanisms the investigators will in this study compare two different exercise modalities, and explore how different biomarkers change in blood, related to exercise.
Detailed description
15 heart transplanted recipients (and 5 healthy controls) will be included in the study. Each patient will have three study-days. The study is designed to be a cross-over study. And randomisation will decide which training they will have som training session 1 and training session 2; Interval or continuous training. Before starting the two training sessions they will measure oxygen uptake and baseline blood samples. During each exercise session the patients will take blood samples during and after exercise. After first study admission the patients will have a wash out period for 1 week until first training session, and another week until the last session.
Interventions
OTHERinterval training
4 intervals with high intensity on treadmill, and approximately 3 minutes rest between intervals.
OTHERmoderate exercise
30 minutes (moderate intensity) aerobic exercise on treadmill without rest.
Sponsors
Norwegian Health Association
Oslo University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
(HTx): * 1-10 years after heart transplantation * Lives in Oslo or near Oslo * Stable health condition * Optimal medical treatment/ medication * No limiting physical handicap * Written consent Inclusion healthy control: * No verified heart disease * Willing to preform the study * Over 18 years * Written consent
Exclusion criteria
* Under 1 year or over 10 year since HTx. * Lives far from Oslo * Unstable health condition * Not optimal medical treatment and/ or medication * Limiting physical handicap * Under 18 years * Not written consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in crp with interval training compared to moderate training | 1 week |
| Changes in interleukin levels with interval training compared to moderate training | 1 week |
| Changes in ICAM levels with interval training compared to moderate training | 1 week |
| Changes in MiRNA levels with interval training compared to moderate training | 1 week |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Oxygen uptake | baseline | V02 peak measured på exercise test on treadmill. |
| Questionnaire of physical activity | baseline | — |
| Questionnaire of quality of life | baseline | — |
Countries
Norway
Outcome results
None listed