Effects of HMB Supplementation on Recovery Following ACL Surgery

Effects of HMB Supplementation on Muscle Mass Following ACL Reconstructive Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02602561

Enrollment

Registered

2015-11-11

Start date

2015-11-30

Completion date

2017-08-31

Last updated

2019-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ACL Injury

Keywords

HMB, beta-hydroxy-beta-methylbutyrate, ACL, surgery, muscle mass

Brief summary

The anterior cruciate ligament (ACL) is a primary stabilizer of the knee, and thus when ACL injury occurs participation in physical activity is compromised. Reconstructive surgery is often necessary to repair the damage which is then followed by a regimen of physical therapy in order to regain full activity. Nutritional intervention after the surgery could help the patient maintain muscle mass during recovery, thus allowing for a quicker return to normal activity.

Detailed description

Beta-hydroxy-beta-methylbutyrate (HMB) is a nutritional supplement shown to improve muscle mass with exercise, and also in muscle loss conditions caused by a decrease in physical activity. Participants will be recruited who will undergo reconstructive surgery for a complete ACL tear and will then enter a standard physical therapy program during a six week recovery period. Subjects will receive either HMB or a placebo supplement during the recovery period. Muscle mass will be measured two weeks prior to the surgery and again after the recovery period using an InBody 720 body composition analyzer. Additionally, the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire will be administered as a measure of recovery and activity level during the study.

Interventions

DIETARY_SUPPLEMENTHMB

DIETARY_SUPPLEMENTPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

* Complete anterior cruciate ligament (ACL) tear * Will benefit from ACL reconstructive surgery * Are able to participate in the physical therapy program * No previous major knee injuries or surgeries * No health conditions affecting muscle mass

Exclusion criteria

* Incomplete ACL tear * Have multiple or bilateral ligament tears * Are unable to participate in the physical therapy program * Have had previous major knee injuries or surgeries * Have health conditions affecting muscle mass

Design outcomes

Primary

Measure	Time frame	Description
Skeletal Muscle Mass by impedance measurement using the InBody 720 body composition analyzer	Six Weeks	Measurement of muscle mass will indicate if the active comparator has preserved or increased muscle mass during the post-surgical recovery period.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026