Intravenous Paracetamol Compared Dexketoprofen for Postoperative Analgesia After Septoplasty

The Efficacy of Intravenous Paracetamol Versus Dexketoprofen for Postoperative Pain Management After Septoplasty: A Prospective Randomized Double Blind Study

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02602197

Enrollment

Registered

2015-11-11

Start date

2013-08-31

Completion date

2016-02-29

Last updated

2015-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Keywords

Paracetamol, Dexketoprofen, postoperative pain, septoplasty

Brief summary

The investigators conducted a prospective, randomized, double blind study to compare the effectiveness of intravenous paracetamol and dexketoprofen for preventing pain during first 24 hours postoperative period in adult patient undergoing septoplasty.

Detailed description

Postoperative pain scores as measured by Visual Analog Scale (VAS) (0 represented no pain and 10 the worst pain ever experienced) at 15, 30, 60 minutes and 2th, 4th, 6th, 12th and 24th hours postoperatively.

Interventions

DRUGParacetamol

After anesthetic induction, the first I.V bolus injections of 1 gr paracetamol (total amount of 100 ml) were given during 15 minutes and then repeated every 6 h until 24 h postoperative period.

DRUGDexketoprofen

After anesthetic induction, the first I.V bolus injections of 50 mg Dexketoprofen (premixed with 0.9 % sodium chloride to total amount of 100 ml) were given during 15 minutes and then repeated every 8 h until 24 h postoperative period.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* After patient's inform consent was approved, a total of 70 ASA (American Society of Anesthesiology) physical status I and II adult patients age 18 to 65 undergoing septoplasty were planned include the study.

Exclusion criteria

* History of clotting disorders or blood dyscrasias, * Gastrointestinal ulcer or chronic dyspepsia, * History of allergy to the study drugs, * Active bleeding or bleeding disorders.

Design outcomes

Primary

Measure	Time frame	Description
Change from pain scores until postoperative 24 hours	Pain scores recorded during postoperative 24 hours.	Pain scores as measured by Visual Analog Scale (VAS) at 15 and 30 minutes, 1h, 2h, 4h, 6h, 12h, and 24 h after surgery

Secondary

Measure	Time frame	Description
Cumulative tramadol consumption during postoperative 24 hours.	First postoperative 24 hours	Cumulative tramadol consumption was recorded during postoperative 24 hours.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026