Diabetes Mellitus, Type 2
Conditions
Keywords
Glycemic control, exercise, Interval Training
Brief summary
A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The time spend with high-intensity (fast) walking is considered to be responsible for the improvements seen, whereas the time spend with low-intensity (slow) walking is considered less important. This study will assess if IW with maintained fast walking time duration but reduced total time duration (i.e. reduced slow walking time duration) is equally effective as IW with a normal time duration. Subjects with type 2 diabetes will be included in a crossover, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions: 1. Sixty minutes of rest (CON) 2. Sixty minutes of classical interval walking (repeated cycles of 3 minutes of fast and 3 minutes of slow walking; IW-60) 3. Fourty-five minutes of time-reduced interval walking (repeated cycles of 3 minutes of fast and 1.5 minutes of slow walking; IW-45). After the interventions subjects will undergo a standardized mixed meal tolerance test with assessment of glycemic control.
Interventions
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Type 2 Diabetes Mellitus * BMI \> 25
Exclusion criteria
* Pregnancy * Smoking * Contraindication to increased levels of physical activity * Eating disorder * Insulin dependence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glycemic control | Within the first 4 hours after the intervention | Glycemic control will be assessed after each intervention. Subjects will receive a standardized mixed meal tolerance test (MMTT), and blood glucose values will be obtained during the test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Matsuda insulin sensitivity index | Within the first 4 hours after the intervention | From the measurements of glucose and insulin during the MMTT, the Matsuda index of insulin sensitivity will be assessed. |
| Stumvoll insulin sensitivity index | Within the first 4 hours after the intervention | From the measurements of glucose and insulin during the MMTT, the Stumvoll index of insulin sensitivity will be assessed. |
| Cederholm insulin sensitivity index | Within the first 4 hours after the intervention | From the measurements of glucose and insulin during the MMTT, the Cederholm index of insulin sensitivity will be assessed. |
| HOMA-2 insulin resistance index | Within the first 4 hours after the intervention | From the measurements of glucose and insulin during the MMTT, the HOMA-2 index of insulin resistance will be assessed. |
Countries
Denmark
Outcome results
None listed