Pyelonephritis, Urinary Tract Infection
Conditions
Keywords
ciprofloxacin, pharmacokinetics, excretion, clearance, infant, children, adolescent
Brief summary
Measuring serum and urine concentrations of ciprofloxacin after IV and oral administration in children aged 3 months - 17 years who are treated for urinary tract infections.
Interventions
DRUGciprofloxacin
Serum and urine concentrations after ciprofloxacin administration. pharmacokinetic testing after ciprofloxacin administration
Sponsors
Universitair Ziekenhuis Brussel
University Hospital, Ghent
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Months to 17 Years
Healthy volunteers
No
Inclusion criteria
* age between 3 months and 17 years of age * confirmed diagnosis of febrile urinary tract infection (a rectal body temperature of 38.5 °C.in combination with either significant leukocyturia or a positive urine nitrite test in a reliable urine sample. * indication for treatment or uroprophylaxis with ciprofloxacin at discretion of the treating physician.
Exclusion criteria
* pregnancy * impaired renal function as defined by 2x serum creatinine level for age and sex * epilepsy * myasthenia gravis * long QT-syndrome * glucose 6 phosphatase deficiency (G6PD) * allergy to one of the substances of cipro * concomitant use of corticosteroids * for the oral group: co medication of antacidic drugs, ferrofumarate, calcium, magnesium or Zinc supplements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum concentrations | 12 hours |
Secondary
| Measure | Time frame |
|---|---|
| Urine concentrations | 12 hours |
Countries
Belgium
Outcome results
None listed