Portal Thrombosis, Pulmonary Embolism, Venous Thrombosis
Conditions
Keywords
Hepatectomy, Prophylaxis
Brief summary
Observational. Retrospective cohort.
Detailed description
Venous thromboembolism (VTE) is a disease that includes both deep vein thrombosis (DVT) and pulmonary embolism (PE). It is a common, potentially lethal disorder that can occur among postoperative patients. Liver surgery implies a prothrombotic state, as a result of an alteration of the equilibrium between synthesis and use of pro and anti coagulant factors after a parenquimal resection. The use of antithrombotic prophylaxis following surgery is not standarized, and current practices vary depending on the attendant surgeon's particular experience or hospital's customs and habits. In published research, postoperative patients have been studied as a whole so far. There is little evidence regarding patients undergoing hepatectomy. Furthermore, the use and need of extended prophylaxis remains unexplored in this group of patients. The objetives of the following study are: * To estimate the incidence of symptomatic venous thromboembolism (VTE) \[deep vein thrombosis (DVT), pulmonary embolism (PE) and fatal PE\] in a third level center in patients undergoing any hepatectomy within 90 days after surgery. * To estimate the incidence of portal thrombosis (PT) in a third level center in patients undergoing any hepatectomy within 90 days after surgery. * To identify and describe factors associated to the development of VTE in patients following hepatectomy. * To identify and describe factors associated to the development of PT in patients following hepatectomy. * To describe major bleedings or minor but clinically relevant bleedings during the period in which those patients received chemical thromboprophylaxis.
Interventions
None listed
Sponsors
Hospital Italiano de Buenos Aires
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Older than 18 years old. * Following hepatic surgery.
Exclusion criteria
* Living donor * Venous thromboembolism within 6 months previous to surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Venous thromboembolism (VTE) | 90 days following surgery | Includes deep vein thrombosis (DVT) and pulmonary embolism (PE) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Portal Thrombosis (PT) | 90 days following surgery | Portal thrombosis |
| Minor bleeding | 90 days following surgery | Any bleeding that doesn't fulfill major bleeding criteria. |
| Major bleeding | 90 days following surgery | Any bleeding causing: death, serious threat to life, requirement of active medical intervention, 2 or more red blood cell units transfusion, localized in retroperitoneum, intracraneal or intraocular |
Countries
Argentina
Contacts
Primary ContactJuan Ignacio Trobbiani, Dr
Backup ContactJuan Cruz Iaquinandi, Dr
Outcome results
None listed